http://www.ksu.edu/biology K-State Division of Biology

 


Stella Y. Lee

Assistant Professor

Ph.D. 2000, Dalhousie University, Canada
Post-doctoral Fellow, Harvard Medical School
Biochemistry and Cell Biology; Protein trafficking


308 Ackert Hall (Office)
323 Ackert Hall (Lab)
(785) 532-3446
sylee@ksu.edu

Lee Lab
Molecular Cellular Developmental Web


Research Focus

We are interested in intracellular protein transport in general.  We have recently identified a negative regulator that modulates the COPI-mediated retrograde transport from Golgi to ER.  Besides the fundamental research, we are also interested in understanding the mechanisms behind transport defects in diseases.  Currently we are focusing on one particular type of lysosomal storage disorders, Neuronal-Ceroid Lipofuscinosis.

Biology rotation students welcome.

Selected Research Publications

Moharir, A., Peck, S.H., Budden, T., and S.Y. Lee. 2013. The Role of N-Glycosylation in Folding, Trafficking, and Functionality of Lysosomal Protein CLN5. PLoS ONE 8(9): e74299. doi:10.1371/journal.pone.0074299

Hsu, V. W., S.Y. Lee, and J.S.Yang. 2009. The evolving understanding of COPI vesicle formation. Nat. Rev. Mol. Cell Biol. 10, 360-364.

Zhang, L.*, S.Y. Lee*, G.V. Beznoussenko, P.J. Peters, J.S. Yang, H.Y. Gilbert, A.L. Brass, S.J. Elledge, S.N. Isaacs, B. Moss, A. Mironov, and V.W. Hsu. 2009. A role for the host coatomer and KDEL receptor in early vaccinia biogenesis. Proc. Natl. Acad. Sci. USA 106: 163-168. (*equal contributions)

Yang, J. S., H. Gad, S.Y. Lee, A. Mironov, L. Zhang, G.V. Beznoussenko, C. Valente, G. Turacchio, A.N. Bonsra, G. Du, G. Baldanzi, A. Graziani, S. Bourgoin, M.A. Frohman, A. Luini, and V.W. Hsu. 2008. A role for phosphatidic acid in COPI vesicle fission yields insights into Golgi maintenance. Nat. Cell Biol. 10: 1146-1153.

Hsu, V.W., J.S. Yang, and S.Y. Lee. 2008. COPI: mechanisms and transport roles.  In Mironov, A. A., Pavelka, M. (Eds) The Golgi Apparatus, State of the art 110 years after Camillo Golgi’s discovery (pp87-105). Springer Wien NewYork.

Lee, S.Y., J.S. Yang, W. Hong, R.T. Premont, and V.W. Hsu. 2005. ARFGAP1 plays a central role in coupling COPI cargo sorting with vesicle formation. J. Cell Biol.  168: 281-290.

Yang, J.S., S.Y. Lee, S. Spano, H. Gad, L. Zhang, Z. Nie, D. Corda, A. Luini, and V.W. Hsu. 2005. A role for BARS at the fission step of COPI vesicle formation from Golgi membrane. EMBO J.  24: 4133-4143.

Yang, J.S., S.Y. Lee, M. Gao, S. Bourgoin, P.A. Randazzo, R.T. Premont, and V.W. Hsu. 2002. ARFGAP1 promotes the formation of COPI vesicles suggesting function as a component of the coat. J. Cell Biol. 159: 69-78.

 

 


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