K-State Division of Biology

Sherry Fleming

Associate Professor

Ph.D. 1998, University of Colorado Health Science Center


18A Ackert Hall
(785) 532-6130

Fleming Research Lab

Molecular Cellular Developmental Biology Web

Description of Research

The focus of my laboratory is on the complement system and other innate immune molecules. Although beneficial during infections, these molecules can cause excessive tissue damage in other conditions. Projects in my laboratory will determine the damaging aspects of the innate immune response in multiple models of tissue injury.

Selected Research Publications

Keith M. Woods, Michael R. Pope, Sara M. Hoffman and Sherry D Fleming Marginal zone B cell production of pathogenic natural antibodies is CR2 dependent but C3 independent J. Immunol.  IN PRESS.   doi:10.4049/jimmunol.1002059

 Sara Hoffman, Hua Wang, Michael Pope and Sherry Fleming. Helicobacter infection alters MyD88 and Trif signaling in response to intestinal ischemia/reperfusion  Exp. Physiology IN PRESS. doi:10.1113/expphysiol.2010.055426

Sara Hoffman and Sherry Fleming. Natural Helicobacter Infection Modulates Mouse Intestinal Muscularis Macrophage Responses. Cell Biochem and Function. 2010; 28: 686–694.

 Sherry D. Fleming, Mike Pope, Sara Hoffman, Tiffany Moses, Urska Bukovnik, John M. Tomich, Lynn Wagner, Keith Woods, and.  Domain V peptides inhibit beta2-glycoprotein I mediated mesenteric ischemia/reperfusion-induced tissue damage and inflammation. 2010 J. Immunol 6168-78  

 Diana J. Hylton, Sara M. Hoffman, N. Van Rooijen, Stephen Tomlinson and Sherry D. Fleming.  Macrophage IL-12 mediates hemorrhage-induced damage in a complement dependent manner. 2010 Shock, In Press. doi: 10.1097/SHK.0b013e3181ed8ec9  

 Michael R. Pope, Sara M Hoffman, Stephen Tomlinson and Sherry D. Fleming. 2010. Complement regulates TLR4-mediated inflammatory responses during intestinal ischemia reperfusion. Mol  Immunol 48: 356–364

 Thurlow, L.R. V.C. Thomas, S. Narayan, S. Olson, S.D. Fleming and L.E. Hancock.  2010. Gelatinase contributes to the pathogenesis of endocarditis caused by Enterococcus faecalis. Infection and Immunity. 78:4936-43

 Hylton, DH, LM Phillips, SM Hoffman and SD Fleming. 2010. Hemorrhage-induced intestinal damage is complement independent in Helicobacter hepaticus infected mice. Shock 34: 467-474.

Sparkes, B., E. Archer, M. Roth, R. Welti and S. D. Fleming. 2010 Ischemia/reperfusion-induced intestinal lipid alterations occur prior to antibody-induced PGE2 production. Biochim. Biophys. Acta. 1801:517-525.

Thurlow, L.R. V.C. Thomas, S.D. Fleming and L.E. Hancock. 2009 Enterococcus  faecalis capsular polysaccharide serotypes C and D and their contributions to host innate immune evasion. Infection and Immunity. 77:5551-5557.

Moses, T.M., Tustin, L.M and S.D. Fleming. 2009 Intestinal ischemia induced TLR4 expression alters PGE2 expression. J. Leuk. Biol. 86: 781-790

Liudmila Kulik, Sherry D. Fleming, Chantal Moratz, Jason W. Reuter, Aleksey Novikov, Kuan Chen, Kathy A. Andrews, Adam Markaryan, Richard J. Quigg, Gregg J. Silverman, George C. Tsokos and V. Michael Holers.  2009. Pathogenic natural antibodies recognizing Annexin IV are required to develop intestinal ischemia-reperfusion Injury.  J. Immunol. 182(9):5363-73.

S.D. Fleming, L.M. Phillips, J. Lambris and G.C. Tsokos. 2008Complement component C5a mediates hemorrhage induced intestinal damage.  J. Surg. Res. 150:196-203.

Sairam V Jabba, Alisha Oelke, Ruchira Singh, Rajanikanth J Maganti, Sherry D Fleming, Susan M Wall, Eric D Green, Philine Wangemann. 2006.  Macrophage invasion contributes to degeneration of stria vascularis in Pendred syndrome mouse model BMC Medicine 2006, 4:37  

Fleming, S.D.  and G.C. Tsokos. 2006. Complement, natural antibodies, autoantibodies and tissue injury.Autoimmun Rev. 5:89-92.

Fleming, S.D. 2006. Natural antibodies, autoantibodies and complement activation in tissue injury.Autoimmunity. 39:379-86


Complete List of Research Publications -(PDF)


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