Contact Dr. Perchellet

28D Ackert Hall
(785) 532-7727
jpperch@ksu.edu
 

 

 

Jean-Pierre H. Perchellet

Professor

Ph.D. 1974, University of Paris VI
Endocrinology


Research Focus

Characterization of the molecular mechanism of action of novel synthetic classes of anticancer drugs

Recent Research Publications

Perchellet, E.M., Y. Wang,K.  Lou, H. Zhao, S.K. Battina, D.H. Hua, and J.P. Perchellet.  2007.   Antitumor triptycene analogs directly interact with isolated mitochondria to rapidly trigger markers of permeability transition.  Anticancer Res 27: 3259-3272.

Perchellet, E.M., Y. Wang, K. Lou, H. Zhao, S.K. Battina, D.H. Hua, J.P. Perchellet. 2007.  Novel substituted 1,4 anthracenediones with antitumor activity directly induce permeability transition in isolated mitochondria. Int J Oncology 31: 1231-1241.

Hua, D.H., K. Lou, S.K. Battina, H. Zhao, E.M. Perchellet, Y. Wang, and J.P. Perchellet.  2006.  Syntheses, molecular targets and antitumor activities of novel triptycene bisquinones and 1,4-anthracenedione analogs. Anti-Cancer Agents in Medicinal Chemistry 6: 303-318.

Perchellet, E.M., M.M. Ward, A.-L. Skaltsounis, I.K. Kostakis, N. Pouli, P. Marakos, and J.P. Perchellet.  2006.   Antiproliferative and proapoptotic activities of pyranoxanthenones, pyranothioxanthenones, and their pyrazole-fused derivatives in HL-60 cells. Anticancer Res 26: 2791-2804.

Wang,Y., E.M. Perchellet, M.M. Ward, K. Lou, H. Zhao, S.K. Battina, B. Wiredu,D.H.  Hua, and J.P. Perchellet.  2006.  Antitumor triptycene analogs induce a rapid collapse of mitochondrial transmembrane potential in HL-60 cells and isolated mitochondria. Int J Oncology 28: 161-172.

Perchellet, E.M., J.P. Perchellet, and P.W. Baures.  2005.  Imidazole-4,5-dicarboxamide derivatives with antiproliferative activity against HL-60 cells. J Med Chem 48: 5955-5965.

Wang Y, E.M. Perchellet, M.M. Ward, K. Lou, D.H. Hua, and J.P. Perchellet.  2005.  Rapid collapse of mitochondrial transmembrane potential in HL-60 cells and isolated mitochondria treated with antitumor 1,4-anthracenediones. Anti-Cancer Drugs 16: 953-967.

Perchellet, E.M., Y. Wang, R.L. Webe, K. Lou, D.H. Hua,and J.P. Perchellet.  2004.  Antitumor triptycene bisquinones induce a caspase-independent release of mitochondrial cytochrome c and a caspase-2-mediated activation of initiator caspase-8 and -9 in HL-60 cells by a mechanism which does not involve Fas signaling.  Anti-Cancer Drugs 15: 929-946.

Perchellet, E.M., Y. Wang, R.L. Weber, B.J. Sperfslage, K. Lou, J. Crossland, D.H. Hua, and J.P. Perchellet.  2004.  Synthetic 1,4-anthracenedione analogs induce cytochrome c release, caspase-9, -3, and -8 activities, poly(ADP-ribose) polymerase-1 cleavage and internucleosomal DNA fragmentation in HL-60 cells by a mechanism which involves caspase-2 activation but not Fas signaling.  Biochem  Pharmacol 67: 523-537.

Wang, B., E.M. Perchellet, Y. Wang, M. Tamura, D.H. Hua, and J.P. Perchellet.  2003.  Antitumor triptycene bisquinones: a novel synthetic class of dual inhibitors of DNA topoisomerase I and II activities.  Anti-Cancer Drugs 14: 503-514.

Perchellet, E.M., B.J. Sperfslage, Y. Wang, X. Huang, M. Tamura, D.H. Hua, and J.P. Perchellet.  2002.  Among substituted 9,10- dihydro-9,10-[1,2]benzenoanthracene-1,4,5,8-tetraones, the lead antitumor triptycene bisquinone TT24 blocks nucleoside transport, induces apoptotic DNA fragmentation and decreases the viability of L1210 leukemic cells in the nanomolar range of daunorubicin in vitro.   Anti-Cancer Drugs 13: 567-582.

Wang, Y., E.M. Perchellet, M. Tamura, D.H. Hua, and J.P. Perchellet.  2002.  Induction of poly(ADP-ribose) polymerase-1 cleavage by antitumor triptycene bisquinones in wild-type and daunorubicin-resistant HL-60 cell lines. Cancer Letters 188: 73-83.

 

   
   
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