Dr. Philine Wangemann

Associate Professor of Anatomy & Physiology

Beta-adrenergic receptors, CGRP-receptors, endothelin receptors, Rho-kinase, KCNQ1-KCNE1 potassium channels, pendrin chloride/bicarbonate transporters, pharmacology, confocal microscopy and microfluorometry, immuno-FRET, micro-Ussing chamber and video-microscopy.

M.S. 1985, Giessen, Germany

Ph.D. 1987 Freiburg, Germany

Phone: 785-532-4863

Fax: 785-532-4557

Email: wange@vet.k-state.edu

Office: 205 Coles Hall

The laboratory is focused on cellular regulation and signal transduction in the inner ear. The first major focus is on the regulation of ion and water transport. Current projects include the biochemical, molecular biological, immunocytochemical, pharmacological and functional identification of beta-adrenergic receptors, muscarinic receptors, KCNQ1-KCNE1 potassium channels and pendrin chloride/bicarbonate transporters. The second major focus is on the regulation of cochlear and vestibular blood flow. Current projects include the elucidation of signal transduction pathways linked to endothelin receptors, CGRP receptors, ryanodine receptors and Rho-kinase. The third major focus is the development of novel antagonists for endothelin receptors and novel inhibitors for Rho-kinase.

Selected Publications

E.Q. Scherer, M. Herzog, P. Wangemann. Endothelin-1 induced vasospasms of the spiral modiolar artery are mediated by a Rho-kinase induced Ca²⁺ sensitization of the contractile apparatus and reversed by CGRP. Stroke. 33: (2003).

M. Herzog, E.Q. Scherer, B. Rorabaugh, M.A. Scofield, P. Wangemann. CGRP receptors in the gerbil spiral modiolar artery mediate a sustained vasodilation via cAMP-induced transient Ca²⁺ decrease and Ca²⁺ desensitization. J. Membrane Biol. 189: 225-236 (2002).

P. Wangemann, J. Liu, E.Q. Scherer, M. Herzog, M. Shimozono, M.A Scofield. Muscarinic receptors control K⁺ secretion in inner ear strial marginal cells. J. Membrane Biol. 182: 171-181 (2001).

P. Wangemann, J. Liu, M. Shimozono, S. Schimanski, and M.A Scofield. K⁺ secretion in strial marginal cells is stimulated via β₁-adrenergic receptors but not β₂-adrenergic or vasopressin receptors. J. Membrane Biol. 175: 191-202 (2000).