Michal
Zolkiewski
Michal
Zolkiewski
Associate Professor of Biochemistry
Protein structure and function; protein folding, misfolding, and aggregation; AAA+ ATPases; molecular chaperones.
B.S.,
University of Warsaw
M.S., University of Warsaw
Ph.D., Institute of Physical Chemistry, Warsaw
Phone: 785-532-3083
Fax: 785-532-7278
Email: michalz@ksu.edu
Office: 111 Burt Hall
Laboratory
website: http://www-personal.ksu.edu/~michalz/lab.htm
Nearly every process in a living cell is carried out by protein complexes with highly organized structure. Among sophisticated protein machines, the AAA+ superfamily of proteins has recently attracted attention of researchers. AAA stands for "ATPases associated with a variety of cellular activities", which implies that these proteins use energy from ATP and perform a variety of functions. Our laboratory performs basic research oriented towards understanding molecular mechanisms underlying the function of AAA+ proteins. We use a combination of biological, biochemical and biophysical experimental approaches to study interactions between proteins, protein localization inside living cells, and structural changes in proteins and protein complexes.
Selected Publications
Liu, Z., Tek,
V., Akoev, V. and Zolkiewski, M.: "Conserved Amino-acid Residues within the
Amino-terminal Domain of ClpB are Essential for the Chaperone Activity", J. Mol.
Biol. 321, 111-120, 2002.
Liu, Z., Zolkiewska, A. and Zolkiewski, M.: "Characterization of Human TorsinA
and its Dystonia-Associated Mutant Form", Biochem. J. 374, 117-122, 2003.
Kedzierska, S., Akoev, V., Barnett, M. E. and Zolkiewski, M.: "Structure and
Function of the Middle Domain of ClpB from Escherichia coli", Biochemistry 42,
14242-14248, 2003.
Akoev, V., Gogol, E. P., Barnett, M. E. and Zolkiewski, M.: "Nucleotide-Induced
Switch in Oligomerization of the AAA+ ATPase ClpB", Protein Sci. 13, 567-574,
2004.