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Publications
Tomich, J. M., Mather, I. H. and Keenan, T. W. (1976) Proteins mask
gangliosides in the milk fat globule and erythrocyte membranes.
Biochim. Biophys. Acta 433, 357-364.
Chibber, B. A. K., Tomich, J. M., Mertz, E. T. and Viswanatha, T.
(1977) Kinetic evidence for an intermediate in the deacetylation of
monoacetyl-chymotrypsin. Proc. Natl. Acad. Sci. USA 74, 510-514.
Eigel, W. N., Hofmann, J. C., Chibber, B. A. K., Tomich, J. M., Keenan,
T. W. and Mertz, E. T. (1979) Plasmin-mediated proteolysis of casein in
bovine milk. Proc. Natl. Acad. Sci. USA 76, 2244-2248..
Tomich, J. M., Marti, C. and Colman, R. F. (1981) Modification of two
essential cysteines in rabbit muscle pyruvate kinase by the nucleotide
analogue 5'-p-fluorosulfonyl-benzoyl guanosine. Biochemistry 20,
6711-6720.
Annamalai, A. E., Tomich, J. M., Mas, M. T. and Colman, R. F. (1982)
Evidence for distinguishable sites of attack in the reactions of
5'-p-fluorosulfonyl-benzoyl adenosine and 5'-p-fluorosulfonyl-benzoyl
guanosine with rabbit muscle pyruvate kinase. Arch. Biochem. Biophys.
219, 47-57.
Tomich, J. M. and Colman, R. F. (1985) Reaction of
5'-p-fluorosulfonyl-benzoyl-1,N6-ethenoadenosine with histidine and
cysteine residues in the active site of rabbit muscle pyruvate kinase.
Biochem. Biophys. Acta 827, 344-357.
Roise, D., Horvath, S. J., Richards, J. H., Tomich, J. M. and Schatz,
G. (1986) A chemically synthesized mitochondrial signal peptide can
form an amphiphilic helix and perturb natural and artificial
phospholipid bilayers. EMBO J. 5, 1327-1334.
Roise, D., Theiler, F., Horvath, S. J., Tomich, J. M., Richards, J. H.,
Allison, D. S. and Schatz, G. (1988) Amphiphilicity is essential for
mitochondrial presequence function. EMBO J. 7, 649-653.
Tomich, J. M., Carson, L. W., Kanes, K. J., Vogelaar, N. J., Emerling,
M. R., and Richards, J. H. (1988) Prevention of aggregation of
synthetic membrane proteins by addition of detergent. Anal. Biochem.
174, 197-203.
Tamm, L., Tomich, J. M. and Saier, M. (1989) Membrane incorporation and
induction of secondary structure of synthetic peptides corresponding to
the N-terminal signal sequences of the glucitol and mannitol permeases
of E. coli. J. Biol. Chem. 264, 2587-2592.
Kersh, G. J., Tomich, J. M. and Montal, M. (1989) The M2 transmembrane
domain of the nicotinic cholinergic receptor forms ion channels in
human erythrocyte membranes. Biochem. Biophys. Res. Comm. 162, 352-356.
Huang, S.-H., Tomich, J. M., Wu, H., Jong, A. and Holcenberg, J. (1989)
Isolation, characterization and sequencing of a cDNA encoding human
deoxycytidine kinase. J. Biol. Chem. 264, 14762-14768.
Barranger, J. A., Ohashi, T., Hong, C. M., Tomich, J. M., Aerts, J. F.
G. M., Tager, J. M., Nolta, J. A., Sender, L. S., Weiler, S. and Kohn,
D. B. (1989) Molecular pathology and therapy of Gaucher disease.
Japanese Journal of Inherited Metabolic Disease 51, 45-71.
Morimoto, S., Kishimoto, Y., Tomich, J. M., Weiler, S., Ohashi, T.,
Barranger, J. A., Kretz, K. A. and O'Brien, J. S. (1990) Interaction of
saposins, acidic lipids and glucosylceramidase. J. Biol. Chem. 265,
1933-1937.
Gatanaga, T., Masunaka, I., Tomich, J. M., Jeffes, E. W. B., Lentz, R.
and Granger, G. A. (1990) Identification of TNF-LT blocking factor(s)
in the serum and ultrafiltrates of human cancer patients. Lymphokine
Res. 9, 225-229.
Wu, L. F., Tomich, J. M. and Saier, M. H. (1990) Structure and
evolution of multidomain, multiphosphoryl transfer proteins: partial
nucleotide sequence of the fructose (Fru) operon in Rhodobacter
capsulatus and comparisons with homologous genes from other organisms.
J. Mol. Biol. 213, 687-703.
Wu, H. P., Holcenberg, J. S., Tomich, J. M., Chen,.J., Jones, P. A.,
Huang, S.-H.and Calame, K. L. (1990) Inhibition of in vitro
transcription by specific double-stranded oligodeoxynucleotides. Gene
89, 203-209.
Montal,
M., Montal, M. S. and Tomich, J. M. (1990) Synporins: A novel
class of synthetic proteins that emulate the pore structure of
biological ion channels. Proc. Natl. Acad. Sci. USA 87, 6929-6933.
Shigematsu, H., Morimoto, S., Kishimoto, Y., Weiler, S., Tomich, J.,
Barranger, J., Shinohara, M., Yeager, A. M. and O'Brien, J. S. (1990)
Saposins (Sphingolipid Activator Proteins) in the Twitcher Mutant
mouse. J. Neurochem. 55, 1659-1662.
Gatanaga, T., Hwang, C., Korr, W., Cappuccini, F., Lucci III, J. A.,
Jeffes, E. W. B., Lentz, R., Tomich, J. M., Yamamoto, R. S. and
Granger, G. A. (1990) Purification and characterization of an inhibitor
(soluble TNF receptor) for TNF and LT obtained from the serum
ultrafiltrates of human cancer patients. Proc. Natl. Acad. Sci. USA 87,
8781-8784.
Jiang, W., Wu, L. F., Tomich, J. M., Saier, M. H. and Niehaus, W. G.
(1990) Corrected sequence of the mannitol (Mtl) operon in Escherichia
coli. Mol. Microbiol. 4, 2003-2006.
Li, Z., Nicoll, D. A., Hilgemann, D. W., Penniston, J. T., Weiss, J.
N., Tomich, J. M. and Philipson, K. D. (1991) Identification of a
peptide inhibitor of the cardiac sarcolemmal Na+-Ca2+. J. Biol. Chem.
266, 1014-1020.
Smith, E. T., Feinberg, B. A., Richards, J. H. and Tomich, J. M. (1991)
Physical characterization of a totally synthetic 2[4Fe-4S] Clostridial
ferredoxin. J. Amer. Chem. Soc. 113, 688-689.
Ohashi, T., Hong, C. M., Weiler, S., Tomich, J. M. and Barranger, J. A.
(1991) Characterization of human glucocerebrosidase from different
mutant alleles. J. Biol. Chem. 266, 3661-3667.
Kaartinen, V., Williams, J. C., Tomich, J. M., Yates, J., Hood, L. E.
and Mononen, I. (1991) Leukocyte glycoasparaginase: Inactivation and
covalent modification with diazo-oxonorvaline. J. Biol. Chem. 266,
5860-5869.
Wu, L. F., Reizer, A., Reizer, J., Cai, B., Tomich, J. M. and Saier, M.
H. (1991) Nucleotide sequence of the Rhodobacter capsulatus fruK gene,
which encodes fructose-1-phosphate kinase—evidence for a
kinase superfamily including both phosphofructokinases of Escherichia
coli. J. Bacteriol. 173, 3117-3127.
Hekman, C., Tomich, J. M. and Hatefi, Y. (1991) Mitochondrial ATP
synthase complex: Membrane topography and stoichiometry of the F0
subunits. J. Biol. Chem. 266, 13564-13571.
Jeffes,
E., Schmitz, K., Yamamoto, R., Tomich, J. M., Beckman, M., Nep,
R. and Kanaver, M. (1991) A simple nonisotropic in vitro bioassay for
LT and TNF employing NaF treated L-929 target cells that detects
picogram quantities of LT and TNF and is as sensitive as TNF assays
done with ELISA methodology. Lymphokine Res. 10, 147-151.
Grove,
A., Tomich, J. M. and Montal, M. A molecular blueprint for the
pore-forming structure of voltage gated calcium channels. (1991) Proc.
Natl. Acad. Sci. USA.88, 6418-6422.
Bechinger, B., Kim, Y., Chirlian, L. E., Gesell, J., Neumann, J. M.,
Montal, M., Tomich, J., Zasloff, M. and Opella, S. (1991) Orientation
of amphipathic helical peptides in membrane bilayers by solid-state NMR
spectroscopy. J. Biomolec. NMR 1, 167-173.
Yamada, Y., Chang, Y.-Y., Daniels, G. A., Wu, L.-F., Tomich, J. M.,
Yamada, M. and Saier, M. H. (1991) Insertion of the mannitol permease
into the membrane of Escherichia coli: Possible involvement of an
N-terminal amphiphilic sequence. J. Biol. Chem 266, 17863-17871.
Smith,
E., Tomich, J. M., Iwamoto, T., Richards, J. H. and Feinberg, B.
(1991) A totally synthetic histidine-2 ferredoxin: Thermal stability
and redox properties. Biochemistry 30, 11669-11676.
Vartak,
N. B, Reizer, J., Reizer, A., Gripp, J. T., Groisman, E. A.,
Wu, L.-F., Tomich, J. M. and Saier, M. H. Jr. (1991) Sequence and
evolution of the FruR protein of Salmonella typhimurium: a pleiotropic
transcriptional regulatory protein possessing both activator and
repressor functions which is homologous to periplasmic sugar binding
proteins. Res. Microbiol. 142, 951-963.
Wu, L. F., Reizer, A., Reizer, J., Cai, B., Tomich, J. M. and Saier, M.
H. (1991) Nucleotide sequence of the fruK gene, which encodes
fructose-1-phosphate kinase: evidence for a kinase superfamily
including both phosphofructokinases of Escherichia coli. J. Bacteriol.
173, 3117-31127.
Portlock,
S. H., Lee, Y., Tomich, J. M. and Tamm, L. K. (1992)
Insertion and folding of the N-terminal amphiphilic signal sequences of
the mannitol and glucitol permeases of Escherichia coli. J. Biol. Chem.
267, 11017-11022.
Montal, M. S., Blewitt, R., Tomich, J. M. and Montal, M. (1992)
Identification of an ion channel-forming motif in the primary structure
of tetanus and botulinum neurotoxins. FEBS Lett. 313 (1), 12-18.
Montal,
M. S., Iwamoto, T., Tomich, J. M. and Montal, M. (1993) Design,
synthesis and functional characterization of a pentameric channel
protein that mimics the presumed pore structure of the nicotinic
cholinergic receptor. FEBS Lett. 320, 261-266.
DeClerck,
Y. A., Yean, T., Lee, Y., Tomich, J. M. and Langley, K. E.
(1993) Characterization of the functional domain of tissue inhibitor of
metalloproteinases-2 (TIMP-2). Biochem J 289, 65-69.
Grove,
A., Tomich, J. M., Iwamoto, T. and Montal, M. (1993) Design of a
functional calcium channel protein: Inferences about an ion
channel-forming motif derived from the primary structure of
voltage-gated calcium channels. Protein Science 2, 1918-1930.
Montal,
M. S., Bühler, L., Iwamoto, T., Tomich, J. M. and
Montal, M. (1993) Synthetic peptides and four-helix bundle proteins as
model systems for the pore-forming structure of channel proteins. II.
Transmembrane segment M2 of the nicotinic cholinergic receptor channel
is a key pore lining structure. J. Biol. Chem. 268, 14601-14607.
Reddy, L. G., Iwamoto, T., Tomich, J. M. and Montal, M. (1993)
Synthetic peptides and four-helix bundle proteins as model systems for
the pore-forming structure of channel proteins. III. Transmembrane
segment M2 of the brain glycine receptor channel is a plausible
candidate for the pore-lining structure. J. Biol. Chem. 268,
14608-14615.
Weiler, S., Carson, W., Lee, Y., Teplow, D. B., Kishimoto, Y., O'Brien,
J. S., Barranger, J. A. and Tomich, J. M. (1993) Synthesis and
characterization of a bioactive 82-residue sphingolipid activator
protein, saposin C. J. Mol. Neurosci. 4, 161-172.
Montal, M. O., Reddy, G. L., Iwamoto, T., Tomich, J. M. and Montal, M.
(1994) Identification of an ion channel-forming motif in the primary
structure of CFTR, the Cystic Fibrosis chloride channel. Proc. Natl.
Acad. Sci. USA 91, 1495-1499.
Iwamoto,
T., Grove, A., Montal, M. O., Montal, M. and Tomich, J. M.
(1994) Chemical synthesis and characterization of peptides and
oligomeric proteins designed to form transmembrane ion channels. Int.
J. Peptide Protein Res. 43, 597-607.
Kanemitsu,
H., Kirino, T., Nakagomi, T., Tsujita, Y., Iwamoto, T.,
Tomich, J. M. and Tamura, A. (1994) Key of induced tolerance to
ischaemia in gerbil hippocampal CA1 is not at trasncriptional level of
hsp70 gene: In situ hybridization of hsp70 mRNA. Neurol. Res. 16,
209-212.
Tomich, J. M., Grove, A., Iwamoto, T., Marrer, S., Montal, M. S. and
Montal, M. (1994) Design principles and chemical synthesis of
oligomeric channel proteins. Chapter 15 in Advances in Chemistry Series
No.235: Biomembrane Electrochemistry Eds. M.Blank and I. Vodyanoy,
American Chemical Society, Washington D.C., pp.329-354. (A peer
reviewed publication)
McCauley,
L.D., Park, C. H., Lan, N. C. Tomich, J. M., Shively, J. E.
and Gee, K. W. (1995) Benzodiazepines and peptides stimulate
pregnenolone synthesis in brain mitochondria. Eur. J. Pharmacol. 276,
145-153.
Rajagopalan, S., Heck, T. J., Iwamoto, T. and Tomich, J. M. (1995) Use
of the 3-nitro-2-pyridine sulfenyl protecting group to introduce
N-branching at lysine during solid-phase peptide synthesis: I.
Application to the synthesis of a peptide template containing two
addressable sites. Intl. J. Prot. Pept. Res. 45, 173-179.
Belogrudov,
G., Tomich, J. M. and Hatefi, Y. (1995) ATP synthase
complex: Proximities of subunits in bovine submitochondrial particles.
J. Biol. Chem. 270, 2053-2060.
Weiler, S., Kishimoto, Y., O'Brien, J. S., Barranger, J. A. and Tomich,
J. M. (1995) Identification of the binding and activating sites of the
sphingolipid activator protein, saposin C with glucocerebrosidase.
Prot. Sci.. 4, 756-764.
Lee, Y., Kinoshita, H., Radke, G., Weiler, S., Barranger, J. A. and
Tomich, J. M. (1995) Position of the sulyhydryl group and the disulfide
bonds of human glucocerebrosidase. J. Prot. Chem. 14, 127-137.
O'Brien, J. S., Carson, G. S., Seo, H.-C., Hiraiwa, M., Weiler, S.,
Tomich, J. M., Barranger, J. A., Kahn, M., Azuma, N. and Kishimoto, Y.
(1995) Identification of the neurotrophic factor sequence of
prosaposin. FASEB J. 9, 681-685.
Barranger, J.A., Tomich, J.M., Weiler, S., Sakallah, S., Sansieri, S.,
Mifflin, T., Bahnson, A. B., Wei, F.-S., Wei, J.-F., Vallor, M.,
Nimgaonkar, M., Ball, E., Mohney, T., Dunigan, J., Ohashi, T., Bansal,
V., Mannion-Henderson, J., Liu, C. and Rice, E. (1995) A review of the
molecular biology of glucocerebrosidase and the treatment of Gaucher
disease. Cytokines and Molecular Therapy. 1, 149-163.
Rajagopalan, S., Radke, G., Evans, M. and Tomich, J. M.(1996) Synthesis
of N-t-boc-4-S-t-butyl-L-thiophenylalanine via palladium catalyzed
cross-coupling reaction of N-t-boc-4-iodo-L-phenylalanine with sodium
t-butylthiolate. Synthetic Comm. 26, 1431-1440.
Pandit,
S. D., Donis-Keller, H., Iwamoto, T., Tomich, J. M., Pike, L.
J. (1996) The MEN 2B point mutation alters the transforming capacity of
the EGF receptor. J. Biol. Chem. 271, 5850-5858.
Belogrudov, G., Tomich, J. M. and Hatefi, Y. (1996) Mitochondrial ATP
synthetase complex: membrane topography and location relative to other
subunits of the small molecular weight subunits e,f and g. J. Biol
Chem. 271 20340-20345.
Feinberg, B.A., Lo, X., Iwamoto, T. and Tomich, J.M. (1996) Synthetic
mutants of Clostridium pasteurianum ferredoxin: Open iron sites and
testing carboxylate coordination. Protein Engineering. 10, 101-107.
Rajagopalan, S., Radke, G., and Tomich, J. M. (1997) A simple procedure
for the preparation of 4-(-mercaptobenzyl)phenoxyacetic acid, a thiol
linker unit used in solid phase synthesis of peptide--thioacids
Synthetic Comm. 27, 187-194.
Christen,R., Jancic,T., Adams, M.W.W., Tomich, J.M. and Smith E.T.
(1997) Physical characterization of a totally synthetic rubredoxin
J.Inorg. Biochem. 65, 53-56.
Wallace, D. P., Tomich, J. M., Iwamoto, T., Henderson, K., Grantham, J.
J. (1997) and Sullivan, L. P. A synthetic peptide derived from the
glycine-gated Cl- channel generates Cl- and fluid secretion by
epithelial monolayers. Am. J. Physiol: 272 (Cell Physiol. 41)
C1672-C1679.
Rajagopalan, S., Broughman, J. R. Jr., Radke, G. and Tomich, J. M.
(1997) Studies on the palladium catalyzed synthesis of various
N-protected 4-S-t-butyl-L-thiophenylalanine derivatives suitable for
use in peptide synthesis. Current Topics in Peptide & Protein
Research, 2, 159-168.
Tomich,
J. M., Wallace, D. P., Henderson, K., Brandt, R., Ambler, C.A.,
Scott, A. J., Mitchell, K. E. Radke, G.,Grantham, J. J. Sullivan, L. P.
& Iwamoto, T. (1998) Aqueous solubilization of transmembrane
peptide sequences with retention of membrane insertion and function.
Biophys J. 74, 256-267.
Tomich, J.M., Iwamoto, T. and Sullivan, L. P.(1998) Application of a
synthetic chloride channel peptide for treatment of Cystic Fibrosis.
Emerging Therapeutic Technologies , Vol 2 Ashley Publications Ltd.
London, UK.
Wallace,
D. P., Tomich, J. M., Eppler, J., Iwamoto, T., Grantham, J.
J.and Sullivan, (2000) L. P. A Channel forming peptide induces Cl-
secretion by T84 cells: Modulation by Ca2+ - dependent K+ channels.
Biochim. Biophys. Acta 1464, 69-82.
Mitchell, K. E., Tomich, J. M., Iwamoto, T. and Freeman, L.C.(2000) A
synthetic peptide based on a glycine-gated chloride channel induces a
novel chloride conductance in isolated epithelial cells. Biochim.
Biophys. Acta 1466, 47-60.
Broughman,
J.R., K. Mitchell, T. Iwamoto, B.D. Schultz, J.M. Tomich.
(2001) Amino-terminal modification of a channel-forming peptide
increases capacity for epithelia anion secretion. Am. J. Physiol: (Cell
Physiol. ) 280: C451-458.
Gao, L., Broughman, J.R., Iwamoto, T., Tomich, J.M., Venglarik, C.J.and
Forman, H.J. (2001) Synthetic Cl- channel restores glutathione
secretion in airway epithelia. Am.J.Physiol (Lung) 281: L24-L30.
Broughman
JR, Shank LP, Takeguchi W, Iwamoto T, Mitchell KE, Schultz,
BD and Tomich JM. (2002) Distinct structural elements that direct
solution aggregation and membrane assembly in the channel forming
peptide M2GlyR. Biochemistry 41,7350-7358.
Broughman
JR, Shank LP, Iwamoto T, Prakash O, Schultz BD, Tomich JM and
Mitchell KE (2002) Structural implications of placing cationic residues
at either the NH2- or COOH- terminus in a pore-forming synthetic
peptide. J Membrane Biol. 190: 93-103.
Matsumoto N, Tsuruoka S, Iwamoto T, Tomich JM, Ito K, Imai M and Suzuki
M. (2003) Alterations in Ion Transport Induced by an Artificial Cl-
Channel in Micro-Perfused Renal Proximal Tubules. J. Membr. Biol.
193:195-200.
Broughman JR, Brandt, R., Hastings C, Iwamoto T, Tomich JM and Schultz
BD, (2004) Anion Channel-Forming Peptide Modulates Transepithelial
Electrical Conductance and Solute Permeability Am. J. Physiol: (Cell
Physiol. ) 286: C1312-1323.
Cook
GA, Prakash O, Zhang K, Shank LP, Robbins, A, Gong Y-X, Iwamoto T,
Schultz, BD and Tomich JM. (2004) Activity and Structural Comparisons
of Solution Associating and Monomeric Channel-Forming Peptides Derived
from the Glycine Receptor M2 Segment. Biophysical J. 86: 1424-1435.
Iwamoto
T, You M, Li E, Spangler J, Tomich J, and
Hristova K. (2005) Synthesis and initial characterization of FGFR3
transmembrane domain: Consequences of sequence modifications.
Biochim.Biophys.Acta-Biomembranes
1668:240-247.
Xinchun Shen, Robyn Moore, Xiaoqun Mo, Shawnalea J. Frazier, Takeo
Iwamoto, John M. Tomich, X Susan Sun (2006) Novel pH Dependent Adhesive
Peptides. In press J.
Nanoscience and Nanotechnology
Shank, L.P., Broughman, J.R., Brandt
R.M., Robbins, A.S., Takeguchi, W., Cook, G.A., Hahn,
L., Radke, G., Iwamoto, T., Schultz, B.D.
and Tomich, J.M. (2006) Redesigning Channel-Forming Peptides: Amino
Acid Substitutions in Channel-Forming Peptides that Enhance Rates of
Supramolecular Assembly and Raise Ion Transport Activity. In press Biophys. J
Johnston, J.M., Cook, G.A., Tomich, J.M., Samson, M.S. (2006)
Conformation And Environment Of Channel Forming Peptides: A Simulation
Study. In press Biophys
J.
Cook, GA, Pajewski R, Aburi M, Smith PE, Prakash O, Tomich
JM, Gokel GW. (2006) NMR Structure and Dynamic Studies of an Anion
Binding Channel-Forming Heptapeptide In press J. Amer. Chem Soc.
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Book
Chapters
Shon, K., Schrader, P., Opella, S., Richards, J. and Tomich, J. M.
(1990) NMR spectra of synthetic membrane bound coat protein species.
UCLA Symposium on Molecular and Cellular Biology, New Series, 109 ed.
D. Live, I. Armitage, and D. Patel, Alan R. Liss, Inc., New York, New
York, pp.109-118.
Grove, A., Iwamoto, T., Montal, M. S., Reddy, G. L., Marrer, S.,
Tomich, J. M. and Montal, M. (1992) Towards a unifying structural motif
for the pore-forming structure of channel proteins. In: "Biotechnology
of Cell Regulation", Vol. 4, R. Verna and Y. Nishizuka (eds.), pp.
89-102.
Grove, A., Iwamoto, T., Montal, M. S., Tomich, J. M. and Montal, M.
(1992) Synthetic peptides and proteins as models for the pore-forming
structure of channel proteins. Methods in Enzymology: Ion Channels,
vol. 207, 510-525, B. Rudy and L. E. Iverson (eds.), Academic Press.
Tomich, J. M. and Richards, J. H. (1992) Synthetic metalloproteins. In:
"Peptides: Chemistry and Biology", J. A. Smith and J. E. Rivier (eds.),
Escom, Leiden, pp. 331-332.
Grove, A., Iwamoto, T., Montal, M. S., Tomich, J. M. and Montal, M.
(1992) Design and synthesis of 4-helix bundle channel proteins. In:
"Peptides: Chemistry and Biology", J. A. Smith and J. E. Rivier (eds.),
Escom, Leiden, pp. 329-331.
McCauley, L. D., Lan, N. C., Tomich, J. M., Shively, J. E.and Gee, K.
W. (1992) Peripheral-type benzodiazepine receptors and the regulation
of steroidogenesis in rat brain mitochondria. In: "Advances in
Biochemical Psychopharmacology," GABAergic Synaptic Transmission 47,
143-147.
Grove, A., Montal, M. S., Reddy, G. L., Marrer, S., Iwamoto, T.,
Tomich, J. M. and Montal, M. (1992) Channel proteins: From anatomy to
design. Jerusalem Symposium, Klumer Academic, Dordrecht, Netherlands,
A. Pullman (ed.). In: Membrane Proteins: Structures Interactions and
Models, pp. 249-268.
Grove, A., Tomich, J. M. and Montal, M. (1992) Molecular design of
oligomeric channel proteins. In: Genetic Engineering, Principles and
Methods, Vol. 14, Setlow, J. K.(ed.), Plenum Press, pp. 163-184.
Tomich, J.M. Channel forming amphipathic helices. (1993) In: "The
Amphipathic Helix", CRC Press Inc., Boca Raton, R. Epand (ed.), Chap.
9, pp. 221-254.
Grove, A., Tomich, J. M., Iwamoto, T. and Montal, M. (1995) Molecular
design of a dihydropuridine-sensitive calcium channel protein.
"Symposium on Ca2+ antagonists in CNS", A. Scriabine
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Patents
Tomich, J. M. and Montal, M. (1994) Biologically Mimetic Synthetic Ion
Channel Transducers. U. S. Patent # 5,368,712— issued
November 29, 1994.
Tomich, J. M. and Iwamoto, T. (1999) Methods for Purifying Synthetic
Peptides.
U. S. Patent # 5,922,840— issued July 13, 1999.
Tomich, J.M., Iwamoto, T. and Sullivan, L (2000). Synthetic
Macromolecular Channel Assembly for Transport of Chloride Ions Through
Epithelium Useful for Treating Cystic Fibrosis U. S. Patent #
6,077,826— issued June 20, 2000
Tomich, J.M., Iwamoto, T., Broughman, J.R., and Schultz, B.D. M2GlyR
Derived Channel Forming Peptides U. S. Patent # 6,750,200 B1—
issued June 15, 2004
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