Photo of JH Chen Jianhan Chen
Assistant Professor of Biochemistry

Computational Biochemistry & Biophysics

B.S.  University of Science and Technology of China (1998)
Ph.D. University of California at Irvine (2002)

Phone: 2-2518
Email :
Office: 34 Chalmers

Chen Lab Webpage

Our general focus is on theoretical and computational studies of biomolecular structure, dynamics and function. We are particularly interested in modeling weakly stable peptides and proteins and understanding their roles in important biological processes including regulation of transcription and translation, signal transduction and disease-related protein misfolding. In collaboration with John Tomich's lab, we also apply computer modeling to determine the selectivity, transport and gating mechanisms of designed anion selective channels.
Selected Publications

J. Chen and C. L. Brooks III. (2007) Critical importance of length scale dependence in implicit modeling of hydrophobic interactions, J. Am. Chem. Soc. 129, 2444-2445. (PubMed)

J. Khandogin, J. Chen and C. L. Brooks III. (2006) Exploring atomistic details of pH-dependent peptide folding. Proc. Natl. Acad. Sci. U. S. A. 103, 18546-18550. (PubMed)

J. Chen, W. Im and C. L. Brooks III. (2006) Balancing solvation and intramolecular interactions: Toward a consistent generalized Born force field. J. Am. Chem. Soc. 128, 3728-36. (PubMed)

J. Chen, W. Im and C. L. Brooks III. (2005) Application of torsion angle molecular dynamics for efficient sampling of protein conformation. J. Comput. Chem. 26, 1565-78. (PubMed)

J. Chen, W. Im and C. L. Brooks III. (2004) Refinement of NMR structures using implicit solvent and advanced sampling techniques. J. Am. Chem. Soc. 126, 16038-16047. (PubMed)

J. Chen, D. Nietlispach, V. A. Mandelshtam, and A. J. Shaka. (2004) Ultra-high resolution 3D NMR spectra from limited-size data sets. J. Magn. Reson., 169, 215-224. (PubMed)

Complete Publications List    (please visit our lab webpage for lastest updates)